منابع مشابه
The Frank--Starling curve.
A basic property of the normal heart is that if its volume is increased, there is an increase in the strength of the contraction. The phenomenon is known as Starling's Law, and as the FrankStarling mechanism. This phenomenon is of great importance. If the heart were unable to increase its output when distended, the distension would become progressively severe. The underlying important relation ...
متن کاملWho discovered the Frank-Starling mechanism?
In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.
متن کاملTitin Determines the Frank-Starling Relation in Early Diastole
Titin, a giant protein spanning half the sarcomere, is responsible for passive and restoring forces in cardiac myofilaments during sarcomere elongation and compression, respectively. In addition, titin has been implicated in the length-dependent activation that occurs in the stretched sarcomere, during the transition from diastole to systole. The purpose of this study was to investigate the rol...
متن کاملRole of the Frank-Starling mechanism in exercise.
The mechanisms which determine the response of stroke volume to mild, moderate, and severe exercise were compared in nine dogs running on a level treadmill. The dogs ran for 3-minute periods at 3-^ mph (mild exercise), 6-8 mph (moderate exercise), and 10—14 mph (severe exercise). Heart rate increased from a standing control value of 107 ± 6 beats/min to 191 ± 10 beats/min in mild, 221 ± 8 beats...
متن کاملSimulation of the Frank-Starling Law of the Heart
We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1979
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.60.3.455632